548 Volatile Sedation in the Burn Intensive Care Unit: A Quality Improvement Initiative

Abstract Introduction Achieving optimal sedation and analgesia in patients with major burn injuries can be challenging. Reliance on benzodiazepines results longer durations of mechanical ventilation, delirium withdrawal. Recent evidence local experience our critical care unit has supported the application volatile agents such as isoflurane for sedation. A audit determined that 70% mechanically ventilated center are managed 3 or more continuous sedative infusions. The aim this initiative was to reduce number infusions maintain target range (SAS 2-4) by 25% 48 hour period following initiation isoflurane. Methods multifaceted education approach applied engage all bedside staff, including surgeons, respiratory therapists nurses. Training occurred though self-directed modules, in-person learning just-in-time training upon new patient initiation. Data from 18 month since implementation were collected retrospectively via manual chart review. Results Since March 2021, sedated using intensive (ICU). Within hours initiation, 50% (9/18) had a decrease 56% (10/18) obtained an level hydromorphone alone. Conclusions Volatile provide safe reliable method injuries. Despite limitations related specialized equipment training, introduction strategy been well received, positive feedback relating both ease titration. Applicability Research Practice Patients require multiple painful surgeries dressing changes. shown infusions, specifically, reliance benzodiazepines.